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KMID : 0043320130360070897
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Archives of Pharmacal Research
2013 Volume.36 No. 7 p.897 ~ p.904
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tert-Butylhydroquinone reduces lipid accumulation in C57BL/6 mice with lower body weight gain
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Nam Kung-Woo
Kim Yong-Hyun
Kwon Hyun-Jung
Rhee Sang-Ki
Kim Wan-Jong
Han Man-Deuk
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Abstract
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tert-Butylhydroquinone (tBHQ) is a commonly used antioxidant additive that is approved for human use by both the Food and Agriculture Organization and the World Health Organization (FAO/WHO). In this study, we examined the effect of tBHQ on body weight gain and found that food supplementation with 0.001 % (w/w) tBHQ inhibited 61.4 % (P < 0.01) of body weight gain in high-fat diet (HFD)-induced C57BL/6 mice, and the oral administration of tBHQ (1.5 mg/kg) reduced 47.5 % (P < 0.05) of body weight gain in normal diet fed db/db mice. The HFD increased lipid deposit in adipocytes, but these were reduced significantly by tBHQ treatment in C57BL/6 mice. tBHQ supplementation significantly lowered the plasma triglyceride and total cholesterol, with reduced size of accumulated fat mass. The rate limiting enzyme of beta-oxidation (ACOX1) was significantly over-expressed in the liver with tBHQ treatment. These results indicate that tBHQ suppresses body weight gain in mice, possibly at least related to the up-regulation of ACOX1 gene expression.
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KEYWORD
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tert-Butylhydroquinone, ACOX1, Real-time RT-PCR, Obesity
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